Coagulation of blood is the condition of clotting of blood. Coagulation of blood is occurs through the serious of various reactions. Coagulation of blood is caused due to the activation of certain substances. Due to the blood clot, the various disturbances have been seen in the normal condition .the risk factor of this disease may leads. To the bleeding. The coagulation of blood is common, since it is formed generally after the injury of some specific kind, leads to the injury of the blood vessel. The factors of coagulation results in the complex condition. The coagulation in some cases may leads to hemorrhages and thrombosis. Coagulation of any kind must be treated immediately to avoid infections in future.